Conversely, ectopic overexpression of SLC5A3 augmented Akt-mTOR activation in NSCLC cells, as the levels of phosphorylated Akt and S6K1 were enhanced in oeSLC5A3-sL-1 and oeSLC5A3-sL-2 pCan-1 cells (Fig. 6B). The gene discussed is RPS6KB1; the disease is non-small cell lung carcinoma.