Using an optimized CRISPR (clustered regularly interspaced short palindromic repeats) screening technique in orthotopic xenograft models, Wei et al., recently discovered SLC5A3 (solute carrier family 5 member 3), a sodium/myo-inositol co-transporter, as a top-ranked gene essential for the tumorigenesis and progression of acute myeloid leukemia (AML) [7]. Here, SLC5A3 is linked to acute myeloid leukemia.