ISYNA1 and acute myeloid leukemia: Wei et al., proposed myo-inositol as a nutrient dependency of AML and SLC5A3 transported myo-inositol to support growth of AML cells, where ISYNA1 (inositol-3-phosphate synthase 1), the rate-limiting enzyme of myo-inositol biosynthesis, was transcriptionally silenced [7].