Culturing MSCs or osteoclast precursors with CM derived from wild-type osteocytes isolated from myeloma-bearing mice showed less Alizarin red-S staining (Fig. 2m) and more multinucleated TRAP+ osteoclast formation (Fig. 2n, left) than observed in myeloma-bearing Ciita-knockout mice. This evidence concerns the gene ACP5 and plasma cell myeloma.