Gal3 and Gal8 can target damaged vacuolar compartments during infection with L. monocytogenes52,53 and S. flexneri52,54,55, as well as with bacteria that reside in membrane-bound compartments such as Legionella pneumophila56, S. enterica52,55, Coxiella burnetti57, and Mycobacterium tuberculosis58. Here, LGALS8 is linked to infection.