To test whether increased MYC expression reduced responsiveness to immune checkpoint blockade in another tumor model, we used the anti-PD-L1 sensitive MC38 model, a C57BL6-derived murine colon adenocarcinoma cell line28 and initiated treatment at 5 mm in length (Fig. 1c, Supplementary Fig. 1c). The gene discussed is MYC; the disease is neoplasm.