We investigated whether MYC exhibited similar effects on MHC-I genes in conditional transgenic models of liver cancer55 and lymphoma;30 indeed, turning MYC off in these models also resulted in an increase in antigen presentation genes (Supplementary Fig. 7a, b), suggesting that the downregulation of antigen presentation genes is dependent on MYC in multiple conditional transgenic cancer models. Here, MYC is linked to cancer.