GRM5 and neuropathy: For instance, a 2010 study that selectively deleted GRM5 in the central nucleus of the amygdala decreased formalin‐induced mechanical sensitivity, while two antisense oligonucleotide knockdowns of GRM1 decreased basal thermal sensitivity and neuropathic mechanical, thermal, and cold sensitivities following chronic constriction injury‐induced neuropathy (Fundytus et al., 2001; Kolber et al., 2010; Young et al., 1998).