While alpha‐CGRP is predominantly expressed in the central and peripheral nervous system and has been extensively studied in relation to a variety of diseases—most notably migraine and cluster headache (Belin et al., 2020; Edvinsson, 2019)—beta‐CGRP is produced mainly in the enteric nervous system and remains comparatively understudied in pain (Muddhrry et al., 1988). The gene discussed is CALCB; the disease is Cluster headache.