This lipodystrophic phenotype was associated with impaired whole-body metabolic function, as judged by slightly reduced glucose tolerance and hyperinsulinemia (Figure 4D–G), as well as a trend towards increased glucagon levels (2.61 ± 0.33 vs. 4.44 ± 0.97 pmol/L, p = 0.122). The gene discussed is GCG; the disease is hyperinsulinism.