At least one of the following: troponin level >0.014 ng/ml, BNP or NT‐proBNP level >400 pg/ml, left ventricular dysfunction, valvular dysfunction, pericardial effusion, coronary artery aneurysm,d pericarditis or myocarditis, endocarditise. The gene discussed is NPPB; the disease is pericardial effusion.