At least one of the following: troponin levels elevated above hospital‐specific reference range,b BNP or NT‐proBNP level >400 pg/ml, ventricular dysfunction, mitral or aortic regurgitation, pericardial effusion, coronary artery aneurysm,c pericarditis or myocarditis, pulmonary edema due to left heart failure, arrhythmia, cardiac arrest, shock requiring vasopressors. This evidence concerns the gene NPPB and edema.