At least one of the following: troponin levels elevated above hospital‐specific reference range,b BNP or NT‐proBNP level >400 pg/ml, ventricular dysfunction, mitral or aortic regurgitation, pericardial effusion, coronary artery aneurysm,c pericarditis or myocarditis, pulmonary edema due to left heart failure, arrhythmia, cardiac arrest, shock requiring vasopressors. The gene discussed is NPPB; the disease is cardiac arrhythmia.