For example, the SNP rs12979680 in the IL28B gene encoding type III IFN-λ-3 has been found to associate with improved clearance and response to treatment in hepatitis C virus infection; however, this polymorphism is vastly more common among individuals of Asian and European ancestry compared to those of African ancestry, and this difference in host genetics is thought to partially underlie disparities in hepatitis C virus infection outcomes between African-Americans and European descendants [111,112]. This evidence concerns the gene IFNL3 and hepatitis C virus infection.