Mice exposed to LD and OVA developed allergic skin inflammation following topical application with OVA, as evidenced by an increase in epidermal thickness, spongiosis, dermal thickness, dermal infiltration by eosinophils, and upregulated mRNA expression of Il33, Tslp, Il4 and Il13 as compared to mice exposed to saline (Fig 2D–2G), features of skin lesions in humans with AD [12]. Here, IL33 is linked to Alzheimer disease.