In people with AD, having APOEε4 is associated with increased burden of tau pathology in medial temporal structures, relative to the cortex.42,43 In our sample greatly enriched for CTE, the strongest associations of APOEε4 with tau pathological burden were in the cortex, as well as the amygdala and entorhinal cortex, but not the hippocampus. The gene discussed is MAPT; the disease is Alzheimer disease.