In addition, overexpression of LINC00638 inhibited the proliferation and migration of TNF‐α‐stimulated RA‐FLS, activate the Nrf2/HO‐1 pathway, decreased the levels of IL‐6, IL‐17, IL‐23, ROS as well as MDA, and increased the level of TAOC. The gene discussed is HMOX1; the disease is rheumatoid arthritis.