Owing to its greater infectivity but lower pathogenicity, as a comparison to its receptor‐binding capacity, it is hypothesized that ACE2 is responsible for increased infectivity whereas NRP1 is associated with increased pathogenicity; in cases of the Omicron variant, the increased binding affinity for ACE2 corresponds to its greater infection rate, while the decreased binding affinity for NRP1 corresponds to a decreased pathogenicity. This evidence concerns the gene NRP1 and infection.