It was found that P/total-mTOR and P/total-P70S6K in WT + CLP mice were significantly increased compared with levels in WT+SHAM mice, while mTOR-related protein expression in WT+CLP mice with 4-PBA intervention was significantly decreased compared with WT+CLP mice (Fig. 4), suggesting that mTOR is activated and involved in ERS caused by sepsis. This evidence concerns the gene MTOR and Sepsis.