Mature cDCs suppress tumor angiogenesis by secreting anti-angiogenic cytokines such as IL-12 and IL-18 as well as anti-angiogenic chemokines including chemokine CXC ligand (CXCL) 9, CXCL10, and CCL 21 (Trinchieri 2003; Curiel et al. 2004a; Piqueras et al. 2006). This evidence concerns the gene IL18 and neoplasm.