BET family members include BRD2, BRD3, BRD4, and BRDT, which are widely involved in regulating the expression of genes related to transcription, DNA repair, immunity, metabolism, and signal transduction; these proteins accomplish this by identifying acetylated histones or transcription factors via their two unique bromodomains and have become promising targets for tumor therapy and viral infection (14, 19). Here, BRD3 is linked to viral infectious disease.