BRD2 and neoplasm: BET family members include BRD2, BRD3, BRD4, and BRDT, which are widely involved in regulating the expression of genes related to transcription, DNA repair, immunity, metabolism, and signal transduction; these proteins accomplish this by identifying acetylated histones or transcription factors via their two unique bromodomains and have become promising targets for tumor therapy and viral infection (14, 19).