CBS and central nervous system cancer: Activation of CBS promoted tumor growth in colon (Phillips et al., 2017; Szabo et al., 2013), ovarian (Bhattacharyya et al., 2013), breast (Sen et al., 2015), prostate (Liu et al., 2016), and lung cancers (Szczesny et al., 2016), whereas loss of CBS in glioma cells increased tumor volume in vivo (Takano et al., 2014).