In BJ-TERT and human mammary epithelial cells (HMEC), overexpressing AKT1E17K, a clinically relevant activated mutant form of AKT1 in multiple cancer types including breast cancer and ovarian cancer (Carpten et al., 2007), also enhanced CBS protein expression (Figure 1—figure supplement 1B). This evidence concerns the gene AKT1 and ovarian carcinoma.