A variety of myeloid cells have been reported to be involved in MS development.[17, 33] To further understand the specific role of microglial miR‐126a‐5p in EAE, we used CX3CR1CreER: miR‐126fl/fl (CX3CR1‐126CKO) mice to delete miR‐126a‐5p specifically in microglia (Figure 3A). This evidence concerns the gene CX3CR1 and myeloid sarcoma.