PRDX5 and rheumatoid arthritis: Auranofin has been used as drugs for anti‐rheumatoid arthritis, antiparasitic and anticancer.[38, 39, 70] Previous study indicated Auranofin could target thioredoxin reductase, an enzyme involved in ROS detoxification.[71] However, as we observed no significant difference of ROS in microglia depletion of miR‐126a‐5p, Auranofin might not exert protective effects on BBB integrity via ROS dependent manner.