It is, therefore, of interest that several proteases were presentin only the AD group (AGA, CTSZ, LGMN, PPAT, QPCTL, and SENP8), absentin the AD group (ATG4C, CTSH, CFH, and PLG), or upregulated and downregulatedin the AD compared to control synaptosomes (Figure 11). This evidence concerns the gene SENP8 and Alzheimer disease.