MAPT and Alzheimer disease: Cleavage site analysisof peptides derived from the tau protein showed that while the preferredamino acids at the P4 to P4′ positions of the P1–↓P1′cleavage site were similar as illustrated by iceLogo assessment (Figure 9a), more detailedanalysis by z-scores showed differences in the frequenciesof residues adjacent to the tau cleavage sites in AD compared to controls(Figure 9b).