The spectrum of CCK and somatostatin neuropeptideswas also altered in AD compared to control brain cortex synaptosomes.The results from this study show that synaptic changes in the molecularspectrum of neuropeptides derived from CHGA, CHGB, SCG2, SCG3, VGF,CCK, and somatostatin occur in human AD brain cortex compared to age-matchedcontrols. The gene discussed is CCK; the disease is Alzheimer disease.