Neutrophil associated inflammatory mediators include vascular endothelial growth factor and matrix metalloproteinases, which inhibit the antitumor effects of helper T-cells (CD4), cytotoxic T-cells (CD8), and natural killer (NK) cells.[36] They also stimulate tumor angiogenesis via remodeling of the extracellular matrix.[41]. This evidence concerns the gene CD8A and neoplasm.