Earlier studies did not detect changes in p16 expression in all MF cells until 2016.[33,34] Kitadate et al speculated that miR-16 directly or indirectly suppresses Bmi1, thereby enhancing p21 expression in MF cells based on their experiments results.[35] It has been confirmed that microRNAs can directly regulate receptor proteins. Here, BMI1 is linked to mycosis fungoides.