The deregulation of signaling pathways, including STAT, Src kinases, c-Myc, COX-2, NFκB, GATA3, TOX, and embryonic stem cell regulators, appears to play an important role in pathogenesis.[13,29] As shown in Figure 2, Fc receptor-like protein 3, along with T plastin, GATA-3, Tox, and miR-214, was significantly higher in Se’zary syndrome patients.[15] Based on the above results, we hypothesized that GATA-3 or/and Tox were activated by activating Fc receptor-like protein 3 and T plastin, and then they or/and enhanced miR-214 transcription. Here, PLS3 is linked to Sezary syndrome.