Interleukin-2 receptor common gamma chain-signaling cytokines, including IL-2, IL-4, IL-7, IL-15, and IL-21 are implicated in early pathogenesis and constitutive.[13,19] As shown in Figure 1, the deregulation of Jak3/STAT3/STAT5 signaling in MF cells can repress the expression of the gene encoding miR-22, which targets the transcriptional co-activator NCoA1.[13]. The gene discussed is JAK3; the disease is mycosis fungoides.