Deregulation of the p53 signaling pathway was also found in MF patient skin biopsies or cells, including My-La, MJ, HUT102, HH, and HUT78.[32] The up-regulated miR-122 inhibits tumor cell apoptosis by Akt/p53 signaling pathway,[14] similarly miR-34a expression level was also increased by p53 signaling pathway in Se’zary syndrome patients skin biosies.[32] However, miR-29a expression was lower in MF patients than in healthy patients because of p53 signaling pathway inhibition.[32]. The gene discussed is TP53; the disease is Sezary syndrome.