MF can develop into a leukemic variant, Sézary syndrome, in which cancer T-cells appear in the skin and blood, or shift to large cell lymphoma.[5] Skin cytokines orchestrate inflammation through their impact on the expression and function of other cytokines, and their downstream effectors (such as STAT and SOCS proteins, microRNA) are frequently observed.[6,7] MicroRNAs (miRNAs) are important molecular markers of MF progression and diagnose.[8]. The gene discussed is CISH; the disease is mycosis fungoides.