The results indicated that high expression levels of AKIP1 were positively related to certain phenotypes of tumor aggressiveness, including tumor size (OR = 2.22, 95% CI: 1.67–2.94, P < .001, Fig. 2C), clinical stage (OR = 2.05, 95% CI: 1.45–2.90, P < .001, Fig. 2D), depth of tumor invasion (OR = 2.98, 95% CI: 2.21–4.02, P < .001, Fig. 2E), and degree of lymph node metastasis (OR = 2.12, 95% CI: 1.75–2.57, P < .001, Fig. 2F). This evidence concerns the gene AKIP1 and metastatic malignant neoplasm in the lymph nodes.