2020c), poricoic acid A, and its derivative compounds (Wang et al. 2018, 2020; Chen et al. 2020a, 2020b). Additionally, some readily available drugs from our previous research have been reported to have anti-fibrosis effects in the UUO model. Rapamycin attenuates TGF-β1-induction which decreases UUO-induced renal fibrosis (Wu et al. 2006). Additionally, combining renin inhibitors valsartan with aliskiren A reduced UUO-induced renal fibrosis (Wu et al. 2010). This evidence concerns the gene REN and renal fibrosis.