To generate tumour‐targeted TPA particles, we induced an insertion mutation of the double cyclic RGD4C in the pIII gene of the filamentous M13KO7 helper phage (Figs 1B, and EV2A and B), termed RGD4C.M13KO7 (Fig EV2A), which contains a medium copy‐number p15A origin of replication. Here, PLAT is linked to neoplasm.