Of note, the promoting effects of miR-380-3p overexpression on Akt pathway activation were abrogated by upregulating PTEN, and conversely, PTEN ablation re-activated the Akt pathway in the PC cells co-transfected with miR-380-3p inhibitor (Figure 4(a-b)). The gene discussed is AKT1; the disease is pachyonychia congenita.