AKT1 and pachyonychia congenita: To ask whether miR-380-3p exerts its tumor-promoting effects in PC through regulating its downstream PTEN-Akt pathway, the PC cells were, respectively, treated with miR-380-3p mimic (miR-mimic), PTEN overexpression vectors (OE-PTEN), and the inhibitor for the Akt pathway (LY294002).