METTL3 and cancer: As previously described, m6A modifications participate in the regulation of cancer progression [13,14], and we evidenced that the m6A-associated regulators, including METTL3 (Figure S2A), METTL14 (Figure S2B), and FTO (Figure S2C), were all aberrantly upregulated in the PC cell lines compared to the normal HPDE cells.