Our study firstly resolved this problem and evidenced that the m6A modifications were highly enriched in the miR-380-3p, and deletion of METTL3 and METTL14 synergistically suppressed miR-380-3p expressions in the PC cells, hinting that m6A methylation is important to sustain the high-levels of miR-380-3p in PC. The gene discussed is METTL3; the disease is pachyonychia congenita.