To investigate this issue, the miR-380-3p mimics and inhibitors, and PTEN overexpression (OE-PTEN) and downregulation (KD-PTEN) vectors were, respectively, delivered into the PC cells, and the cells were grouped as follows: Control, miR-mimic group, miR-inhibitor group, miR-mimic + OE-PTEN group, and miR-inhibitor + KD-PTEN group. Here, PTEN is linked to pachyonychia congenita.