An analysis of miRNA expression in liver tissue of murine models of dyslipidemia and atherosclerosis reported a significant up-regulation of miR-27b, and subsequent mechanistic studies in human hepatocytes demonstrated that miR-27b inhibits the expression of several important lipid-metabolism genes, including Pparg, Angptl3 and Gpam [78]. Here, ANGPTL3 is linked to atherosclerosis.