To reveal the potential mechanism of Repeated sevoflurane exposure induced cognitive impairment, we perfromed RNA-seq analysis between between IL-17A−/− and IL-17A−/− + Sev mice, the results showed L-17A related gene such as Ccl20, Cxcl6, Tnn and Slc4a1 were not enriched (Figure 2(b,d)) and IL-17A signaling pathway were not enriched in KEGG analysis either (Figure 3(b)). Here, CXCL6 is linked to Cognitive impairment.