AKT1 and schizophrenia: Schizophrenia can be viewed as a systemic disorder with parallel manifestations in both the brain and peripheral tissues.20–22 Although many studies have assessed expression of prominent genes of the Akt/GSK3β/mTORC1 pathway in peripheral blood mononuclear cells (PBMCs) from FEP patients,23–26 the coordinated signaling output of the pathway has not been described comprehensively so far.