It should be stressed out that we measured the phosphorylation of all Akt isoforms (Akt1, 2, and 3), which are all expressed in human PBMCs.23 Besides Akt1 variants,9,10 recent GWAS studies have also suggested Akt3 as a susceptibility locus for schizophrenia.38 When we studied the effects of APD treatment, the mean change in Akt phosphorylation was negligible (figure 3). The gene discussed is AKT3; the disease is schizophrenia.