mTOR operates in 2 distinct complexes and is recognized as a crucial protein for human cancer, metabolic diseases, and neurodevelopmental disorders.2,5,6 Furthermore, mTOR is a core signaling hub that bears connections to both the immune and metabolic responses.6,48 Our results suggest that PBMC mTORC1 activity may be the integrator of altered peripheral immune and metabolic states in FEP patients. Here, MTOR is linked to metabolic disease.