CCND1 and hepatocellular carcinoma: Furthermore, Michaloglou et al. showed that the mTORC1/2 inhibitor AZD2014 inhibits the phosphorylation of RB and cyclin D1, which is consistent with the reduced phosphorylation of S6K and 4EBP‐1 observed in ER+ MCF‐7 and HCC‐1428 cells.38