Pro-inflammatory cytokine-secreting Tregs such as IFN-γ-producing FOXP3+ cells, IL-4-producing FOXP3+ cells, and IL-17-producing FOXP3+ cells are also noticed in asthmatic patients, which are strongly correlated with the severity of asthma and might be insensitive to corticosteroids (125, 126). The gene discussed is FOXP3; the disease is asthma.