CD4 and tuberculosis: Figure 1 illustrates that neutrophilic/granulocytic-type N-MDSCs were higher among PBMCs of TB patients and there was a marked reduction in the activation of CD8+T cells compared to CD4 T cells. Although M-MDSCs were lesser in PBMCs, herein, we pursued their analysis of because of their potential role during TB. CyTOF analysis was done to confirm the presence of N-MDSCs and M-MDSCs in samples of TB patients and compared with donors; Supplementary Figure 3 shows the t-SNE plots of immune cell composition and Supplementary Table 1 indicates the clinical status of TB patients and controls.