reported that GELN RNAs ameliorate mouse colitis by inducing gut probiotic Lactobacillus rhamnosus GG (LGG) indole-3-carboxaldehyde, which promotes the expression of interleukin (IL)-22 in gut lymphocytes of mice through activation of the aryl hydrocarbon receptor (AHR) signaling pathway (28). This evidence concerns the gene IL22 and colitis.