In gastric tissue injury models, a precancerous lesion, referred to as spasmolytic polypeptide expressing metaplasia (SPEM), can be identified in two unique settings, viz., acute drug injury and chronic autoimmunity, based on the differential expression of the SPEM-defining transcript spasmolytic polypeptide (also known as Trefoil Factor 2 or TFF2) (47). This evidence concerns the gene TFF2 and Autoimmunity.