Anti-PD-L1 monotherapy (durvalumab) was observed as part of a randomized expansion phase 1/2 study in 104 HCC patients who progressed or refused sorafenib treatment, with an ORR of 10.6% (95% CI, 5.4-18.1) and a median OS of 13.6 months (8.7 to 17.6) (89). The gene discussed is CD274; the disease is hepatocellular carcinoma.