In this study, we used ChIP-Seq analysis of histone H3K4me3-marked, to identify various TSSs associated with LPS-, TNF-α-, and IL-10-stimulated neutrophils from healthy individuals, as well as neutrophils derived from patients with sepsis (systemic septic inflammation with LPS-stimulated neutrophils), NMOSD (aseptic inflammation with pre-activated neutrophils), and periodontitis (local self-limiting septic inflammation with IL-10-positive neutrophils). The gene discussed is TNF; the disease is Sepsis.