In this small cohort retrieved from the past 5 years in our medical centre, WBE therapy based on SOC displayed advantages of quick recovery of Hb levels in refractory severe SLE-AIHA patients, which was superior to traditional IVIG/RTX treatment in shortening the duration of hypoxic conditions and protecting vital organs from the functional deterioration. This evidence concerns the gene GSTM1 and systemic lupus erythematosus.