Additionally, the interactions of Epidermal Growth Factor Receptors (EGFR)/Signal transducer and activator of transcription 3 (STAT3) or the epidermal growth factor receptor variant III (EGFRvIII)/STAT3 signaling axes with COX2 downstream pathways contributes to glioma angiogenesis (Figure 2) (9). The gene discussed is STAT3; the disease is central nervous system cancer.