MRC1 and type 2 diabetes mellitus: Such increased inflammatory phenotype in KO-T2D macrophages persisted into the late stage of diabetes, similar results of higher Ly6C+ population and lower CD206+ population were observed at 8 weeks after STZ injection (Supplementary Figures S3B–E), which may contribute to the development and progression of cardiac dysfunction under T2D conditions (Figures 3F, G).