Such increased inflammatory phenotype in KO-T2D macrophages persisted into the late stage of diabetes, similar results of higher Ly6C+ population and lower CD206+ population were observed at 8 weeks after STZ injection (Supplementary Figures S3B–E), which may contribute to the development and progression of cardiac dysfunction under T2D conditions (Figures 3F, G). Here, MRC1 is linked to diabetes mellitus.