We furthermore found an increased odds of PRISm with higher IgA (OR: 1.14; 95% CI: 1.00-1.31) and IgG levels (OR: 1.11; 95% CI: 1.05-1.17), while none of the Igs was associated with COPD (Table 5). Here, CUBN is linked to chronic obstructive pulmonary disease.