The results showed that compared with the control group, the proportions of naive B cells, CD8 T cells, CD4 memory resting T cells, CD4 memory activated T cells, and resting natural killer (NK) cells in SLE were significantly lower, while monocytes, macrophages M0, activated dendritic cells, neutrophils were higher (Figure 5A). Here, CD8A is linked to systemic lupus erythematosus.