Generally speaking, we identified six genes as prospective SLE biomarkers (nSLE = 1315, nnormal =122), including ABCB1, EIF2AK2, HERC6, ID3, IFI27, and PLSCR1, and demonstrated that ABCB1, EIFI27, and PLSCR1 might be suitable for the Chinese population. Here, ID3 is linked to systemic lupus erythematosus.