However, conventional dendritic cells (cDCs) obtained from Lgp2-/- or with a point mutation in the LGP2 helicase domain (K30A) were reported to be unable to release IFNβ in response to infection with RNA viruses (picornaviridae, EMCV, and mengovirus), with the exception of influenza virus, while they efficiently responded to synthetic poly I:C (88). Here, DHX58 is linked to infection.