In multiple myeloma (MM), the dual inhibition of H3K27 and H3K9 methyltransferases EZH2 and G9a leads to the de-repression of ERVs genes, the activation of IFN signaling, the suppression of IRF4-MYC axis and the impairment of xenograft formation by MM cells in mice (143). The gene discussed is IRF4; the disease is Miyoshi myopathy.