In a Drosophila model of AD achieved by expressing a mutant isoform of Tau protein (tauR406W) and analyzing the data obtained from head samples at day 10 of adulthood, an age at which neuronal deficits become evident, the same authors identified a significant de-repression of retroviral elements, similarly to what observed in human samples (136). Here, MAPT is linked to Alzheimer disease.