To know whether the serum calcium levels of SLE patients were correlated with their levels of Th1/Th2 cytokines, the IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ in sera of SLE patients with normal (Ca2+ N) or low (Ca2+ L) serum calcium levels and healthy people were detected using cytometric bead array (CBA) and the correlation to the serum calcium levels was analyzed. This evidence concerns the gene TNF and systemic lupus erythematosus.