After analysis by gating CD8+ cells from the lymphocytes of PWBCs (Figure 4B), it was found that the percentage of CD69+CD8+ T cells and the expression levels of CD69 on CD8+ T cells were significantly increased in the cultured PWBCs of both SLE and health background stimulated by PMA, and there was no difference between them, but GCs had no such effect (Figure 4C). This evidence concerns the gene CD69 and systemic lupus erythematosus.