The results showed that in both Ca2+ N and Ca2+ L groups of the SLE patients, there were the significant differences in the increase of the CD8+ T cell–percentages and the decrease of the CD16+CD56+ NK cell percentages, and the decrease of the counts of CD4+ T cells and CD16+CD56+ NK cells compared with healthy people. Here, CD4 is linked to systemic lupus erythematosus.