The researchers found that knockout of the CGI-58 (comparative gene identification-58) gene in obese mouse macrophages resulted in mitochondrial dysfunction and reactive oxygen species-mediated oxidative stress in ATM, resulting in the activation of NLRP3 inflammasome and downstream caspase-1, leading to the exacerbation of insulin resistance and hyperglycemia (83). The gene discussed is ATM; the disease is Insulin resistance.