We also compared HIV patients according to comorbidities (i.e., mycosis, syphilis, retinitis, allergies, cancer, diabetes, renal disease, hypertension), and observed that those with any comorbidity presented higher values of two cytokines in comparison with those without comorbidities: IFN-gamma (Any comorbidity: 3.43, IQR:2.80-4.27; Without Comorbidity: 2.0, IQR: -2.09-2.33; p=0.024) and IL-4 (Any comorbidity: 3.23, IQR: -1.95-43.78; Without Comorbidity: -6.64, IQR:-6.64—6.63; p=0.015) (Figure 4). This evidence concerns the gene IL4 and fungal infectious disease.