Another seven-marker (ApoA-1, CFH, CRP, IFN- gamma, CXCL10, SAA, and transthyretin) serum protein biosignature for the diagnosis of TB, irrespective of HIV-infection status or ethnicity in Africa, were identified as a promising biomarker for field friendly point-of-care screening test for pulmonary TB (27). Here, CFH is linked to HIV infectious disease.