In addition, the combination model of IFIT3 and IFIH1 had a definite diagnostic accuracy in detecting fever among patients with SLE, and the regression model of the two hub genes was −18.6335 + −1.5369*IFIT3 + 3.2156 × IFIH1 (AUC = 0.883). This evidence concerns the gene IFIT3 and systemic lupus erythematosus.