Emerging as a potential target, activation of Nrf2/HO-1 pathway has shown to be an effective way to attenuate ferroptosis-induced injuries and diseases, including LPS-induced acute lung injury [42], contusion spinal cord injury [43], type 2 diabetic osteoporosis [44], and radiation-induced intestinal epithelial cell death [45]. Here, HMOX1 is linked to injury.