PKM and cancer: It also provides materials for its lipid, nucleic acid, and amino acid metabolism, thus promoting its malignant behavior [57]; glucose transporter (GLUT) and several glycolytic enzymes, such as hexokinase (HK), pyruvate kinase (PKM), enolase (ENO), and lactic dehydrogenase (LDH), are aberrantly overexpressed in cancers, which contributes to metabolic reprogramming.