And in our study, for the first time, the intimate association of the other 3 miRNAs (hsa-miR-18b-3p and hsa-miR-519e-5p) and 4 genes (IFNAR2, ARHGAP5, FLNC, and NTF3) with osteoporosis was discovered. This evidence concerns the gene ARHGAP5 and osteoporosis.