VEGFA and neoplasm: VEGFA at present is considered to be the strongest vascular permeability factor; the immune response, inflammation, mastitis, tumor, ischemia, and hypoxia play a key role in many physiological and pathological cell infiltration, stimulate the production of endothelial cell matrix degradation of protease, cause hemal wall integrity being impaired, and increase permeability leading to the vascal process [53].