Representative Western immunoblot shows the molecular forms and species MMP-8 detected in human oral fluid/mouthrinse samples by both polyclonal and monoclonal anti-MMP-8 antibodies (Figure 1); upon activation, latent proMMP-8 is converted to lower molecular size active forms/species and fragmented species that can be detected especially in the oral fluids/mouthrinse of the periodontitis and peri-implantitis patients [2, 6, 10, 13, 17, 19]. The gene discussed is MMP8; the disease is Peri-Implantitis.