MMP-8 is expressed at the myelocyte phase during neutrophil development in the bone marrow, and stored and prepacted as latent MMP-8 in subcellular neutrophil-specific granules to be the degranulated and released extracellularly at the sites of inflammation in gingiva during periodontitis and peri-implantitis [10, 11]. This evidence concerns the gene MMP8 and periodontitis.