The aMMP-8 biomarker was found to be the most optimal for chairside point-of-care online and real-time quantitative diagnostics for both diabetes and periodontitis at the dentist's office, outperforming other biomarkers such as total MMP-8, active and total MMP-9, TIMP-1, myeloperoxidase (MPO), human neutrophil elastase (HNE), and calprotectin [98]. This evidence concerns the gene MPO and diabetes mellitus.