Studies have shown that the activation of inflammasomes in the NAFLD liver leads to the expression of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and interleukin-18 (IL-18) and promotes cell apoptosis by activating caspase-1 (48, 49). The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatotic liver disease.